Biotechnology companies across the globe are advancing scores of clinical trials in the race to develop effective vaccines and therapies that can be used against the novel coronavirus and the COVID-19 disease it causes. Results for tests are also trickling out into the news media, offering the public a view of possible vaccine design and manufacture processing.
British American Tobacco (BTI 1.23%), through Kentucky Bioprocessing (KBP) and Reynolds American is working toward a vaccine against COVID-19 that's being manufactured in tobacco plants. Tobacco plants are considered excellent platforms for producing vaccines at a low cost.
Kentucky Bioprocessing producing pharmaceutical proteins
Kentucky Bioprocessing specializes in the production of pharmaceutical proteins grown with the use of plants. These proteins are used in antibodies, hormones, enzymes, and (of course) vaccines. The COVID-19 vaccine will prove additionally useful as an experiment regarding the speed of commercialization for such essential medicines.
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Kentucky Bioprocessing says that once approved for commercial production, its method of producing vaccines via tobacco plants could shorten the manufacturing timetable to as few as six weeks. Before such approval, the vaccine must go through tests; after production was announced in the first quarter of this year, the company now believes the vaccine is ready for phase 1 clinical trials. These will determine the ideal dose amount that provides a benefit while minimizing side effects.
A plant design
Kentucky Bioprocessing uses Nicotiana benthamiana, a herbaceous plant similar to the tobacco plant that isn't used in smoking-related products. Instead, this variety of plant is used to create recombinant proteins for use in vaccines. .
A COVID-19 vaccine could take 12 to 18 months to design and enter into clinical tests. BAT's vaccine candidate could substantially shorten that timeline -- the company has already submitted a pre-investigative new drug application to the U.S. Food and Drug Administration (FDA), which has acknowledged the submission. The company is also looking to other world governments for support for the vaccine.
Big tobacco fighting for a vaccine share
Medicago, a biotech company in Quebec, is developing a coronavirus vaccine using the same variety of plants. Medicago is a joint venture between business units of Philip Morris International (PM 0.76%) and Mitsubishi Chemical Holdings Corporation. On May 15, the company announced that its vaccine candidate for COVID-19 produced positive antibody response after 10 days in vivo during single dosing of mice .
The company produced a virus-like particle just 20 days after acquiring a gene of the SARS-CoV-2 virus, then initiated pre-clinical testing. Medicago notes that it is bidding for a phase 1 clinical trial in the summer , which will evolve toward phase 2 studies by the end of 2020.
Broadly speaking
British American Tobacco is a buy. Its COVID-19 vaccine is a sign that the cross-industry development of coronavirus therapies and vaccines will be necessary for economic recovery. However, these things will also be affected by the unpredictability of the s needed to develop promising vaccine candidates. Investors should keep an eye on the progress of phase 1 trials to evaluate whether tobacco-based vaccines can deliver on the promises they offer. For The Hill, Dr. Anthony Fauci, director of the National Institute for Allergy and Infectious Diseases, said that an aggressive investment into vaccine production could make it possible to distribute millions of doses as 2020 ends.
Fauci said that it is an "aspirational" goal, adding that candidate vaccines fail more often than they succeed, barring even promising vaccine entries. Though it is conjecture, Fauci's comments should offer investors an insight into how the rush for a COVID-19 vaccine crosses industries. Tobacco companies like BAT and PMI are experiencing new attention for their work to develop plant-based vaccines for COVID-19 and potentially other vaccine candidates. How you take these comments is entirely up to you.
